NFL Week 6 Opening Odds, Betting Lines, and Spreads: Fade the Fading Panthers

Today's NFL expert best bets and free picks for today

As NFL Week 6 approaches, only two teams remain unblemished in their quest for victory. The San Francisco 49ers and the Philadelphia Eagles have upheld their perfect records, hinting at a potential rematch of last year’s NFC Championship game come January.

With most sportsbooks unveiling their lines for the upcoming week on Sunday night, let’s dive into the opening Week 6 lines. Be sure to stay tuned to our NFL predictions, where we’ll provide our insights on the side and total for every game throughout the week. Our experts have been on fire, cashing in on multiple parlays and boasting an impeccable 4-0 NFL best bets record in Week 5, extending their streak to an impressive 14-3 run!

NFL Week 6 Opening Lines and Odds

(Odds available at Sportsbook at the time of publishing.)

  1. Denver Broncos +10.5 (-105) vs. Kansas City Chiefs -10.5 (-115) – Thursday Night Football
  2. Baltimore Ravens -4 (-110) vs. Tennessee Titans +4 (-110)
  3. Carolina Panthers +14 (-110) vs. Miami Dolphins -14 (-110)
  4. Detroit Lions -3 (-120) vs. Tampa Bay Buccaneers (+100)
  5. Seattle Seahawks +3 (-120) vs. Cincinnati Bengals -3 (+100)
  6. San Francisco 49ers -3.5 (-110) vs. Cleveland Browns +3.5 (-110)
  7. Washington Commanders +2.5 (-110) vs. Atlanta Falcons -2.5 (-110)
  8. Minnesota Vikings -3 (-120) vs. Chicago Bears +3 (+100)
  9. Indianapolis Colts +4.5 (-110) vs. Jacksonville Jaguars -4.5 (-110)
  10. New Orleans Saints -2.5 (-110) vs. Houston Texans +2.5 (-110)
  11. New England Patriots +2.5 (-105) vs. Las Vegas Raiders -2.5 (-115)
  12. Arizona Cardinals +6 (-110) vs. Los Angeles Rams -6 (-110)
  13. Philadelphia Eagles -6 (-110) vs. New York Jets +6 (-110)
  14. New York Giants +14 (-105) vs. Buffalo Bills -14 (-115) – Sunday Night Football
  15. Dallas Cowboys -2.5 (-110) vs. Los Angeles Chargers +2.5 (-110) – Monday Night Football

Best Early Bet for NFL Week 6: Miami Dolphins -14 over Carolina Panthers (-110)

While it’s never a thrilling prospect to lay two touchdowns in the NFL, a compelling opportunity arises to continue fading one of the league’s struggling teams. The Dolphins are poised to be a popular choice this week, and for good reason. There’s little justification to support the Panthers, a team with glaring defensive vulnerabilities, as they face off against the NFL’s most prolific offense this season. Carolina’s defense was recently dismantled by Detroit, and the sheer speed of the Miami squad represents a significant upgrade from the Lions. Moreover, the Dolphins will enjoy the comforts of home after a convincing 31-16 victory over the Giants, even though they didn’t perform at their best for extended periods. While there may be sharper options to monitor this week, seizing the Dolphins at a two-touchdown or better advantage appears enticing.

Stay tuned for our forthcoming NFL Week 6 picks for every game as we continue to dissect the matchups!

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